Senior Director, Business Insights and Technology- Research (Clinical Pharmacology & Pharmacometrics)

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Role Overview 

Bristol Myers Squibb is seeking a technology leader with deep roots in clinical pharmacology and pharmacometrics (CPP) to serve as the Senior Director, Clinical Pharmacology & Pharmacometrics Technology within Research Business Insights & Technology (BI&T). This leader owns the technology products, modeling and scientific-computing platforms, data integrations, workflow automation, and validated operational services that enable CPP work end to end—from quantitative preclinical-to-clinical bridging through clinical PK/PD, dose and regimen decisions, and submission-ready outputs. 

This role supports the quantitative CPP layer across Research and Development, including pharmacometric workflows, clinical PK/PD systems, modeling platforms, reporting automation, regulatory evidence generation, and the governed operational capabilities required to run these workflows at scale. 

Reporting to the Vice President, Research Business Insights & Technology, this leader will operate as part of a unified BI&T leadership team alongside peers in enterprise architecture, cloud and infrastructure, R&D data, cybersecurity, and quality/compliance IT and act as a trusted partner to Research and Development leadership. The role carries accountability for the reliability, fit-for-purpose evolution, and long-term scaling of the CPP technology stack and workflow ecosystem, while working in a highly matrixed model with scientific leaders, data teams, lab-platform teams, and regulatory-facing partners. 

Mission & Impact 

• Provide a scalable application and workflow backbone for CPP modeling and simulation, supporting preclinical-to-clinical translation, dose selection, and model-informed development decisions 

• Deliver modern scientific-computing and modeling environments (HPC/cloud compute, containerized toolchains, reproducible analysis workspaces) in partnership with the Research Compute team that improve the speed, reproducibility, traceability, and inspection-readiness of CPP workflows 

• Strengthen regulatory submissions through robust reporting, reusable quantitative evidence generation, and auditable outputs that support documents such as clinical pharmacology summaries and model-based appendices 

• Enable governed automation of priority CPP workflows using agentic AI, including reporting, modeling and simulation, execution, review, and knowledge reuse to reduce cycle time of deliverables. 

• Create a durable technology foundation for end-to-end CPP that can scale with pipeline demand and integrate cleanly across the broader Research and Development ecosystem 

Sub-Areas in Scope 

• Clinical pharmacology and pharmacometrics applications, including PK Non-Compartmental Analysis (NCA), population PK, PK/PD, exposure-response, dose optimization, and model-informed decision support 

• PBPK, QSP, drug-drug interaction, and other quantitative modeling environments used in CPP workflows including licensing, deployment, validation, and vendor relationships 

• Clinical PK/PD systems and operational tooling that support end-to-end CPP execution 

• Reporting automation, and submission-support workflows for quantitative regulatory deliverables 

• Quantitative translational workflows that bridge preclinical and clinical evidence in support of CPP decision-making 

• Workflow governance, audit trails, validation support, access controls, and inspection-ready operational practices for regulated quantitative environments 

• AI/ML and advanced-analytics capabilities (including LLM-assisted modeling, review, and reporting) that improve CPP workflow efficiency—with associated MLOps, model governance, and responsible-AI controls 

• Service management for the CPP technology estate: incident, problem, and change management; user support; training; and vendor performance management 

Key Responsibilities 

• Serve as the single BI&T point of accountability for CPP technology, applications, workflows, and support services end to end 

• Define and own the multi-year CPP technology strategy, architecture, and product roadmap, aligned with BI&T enterprise standards and R&D scientific priorities 

• Partner across Research and Development to integrate CPP workflows with the scientific, data, and operational capabilities required for model-informed drug development 

• Own the lifecycle of CPP applications, modeling environments, scientific-computing infrastructure, reporting pipelines, and operational support, including build/buy/partner decisions 

• Ensure operational excellence, reliability, governance, and continuous improvement across modeling environments, clinical PK/PD systems, reporting workflows, and submission-support applications 

• Lead engineering delivery of workflow automation—model execution orchestration, simulation at scale, reporting pipelines, traceability, review workflows, and evidence reuse—using modern software-engineering practices 

• Own validation and compliance for regulated CPP systems in partnership with Quality, Regulatory, and IT Compliance, ensuring systems are inspection-ready and documentation is audit-grade 

• Partner with Unified Lab & Experimental Platforms, Target & Disease Biology, and In-Vivo & Non-Clinical Pharmacology where translational science, lab systems, diagnostics, biomarker workflows, or bioanalytical capabilities intersect with CPP needs 

• Partner with the R&D Data organization on underlying data-product strategy, integration, and fit-for-purpose data access 

• Lead and grow a team of scientific technologists, product leaders, and specialized engineers aligned to this domain 

Required Experience & Qualifications 

• Advanced degree (Ph.D. preferred) in Pharmacometrics, Clinical Pharmacology, Pharmaceutical Sciences, Biostatistics, or related quantitative field 

• 12+ years of experience in pharmaceutical R&D or life-sciences technology, with a substantial portion in technology, informatics, or platform leadership roles supporting clinical pharmacology, pharmacometrics, or model-informed drug development 

• Hands-on familiarity with the CPP toolchain (e.g., NONMEM, Monolix, R, Python, PBPK/QSP platforms) and the ability to engage credibly with practicing pharmacometricians on their workflows and pain points 

• Proven experience implementing or leading CPP applications, PBPK and QSP environments, clinical PK/PD systems, or quantitative workflow automation 

• Demonstrated experience supporting regulatory submissions, quantitative reporting, and governed workflows in Development-facing settings 

• Experience applying AI/ML, LLM-based tooling, or advanced automation to quantitative modeling, reporting, or regulated scientific workflows, including MLOps and model-governance considerations (preferred) 

• Director or Senior Director-level leadership experience; experience building and scaling a specialized scientific technology team is a strong differentiator 

Critical Capabilities 

• Scientific Fluency in Clinical Pharmacology and Pharmacometrics — Sufficient depth to earn credibility with quantitative scientists and domain leaders across CPP 

• Technology & Platform Leadership — Sets architecture direction and delivers reliable, secure, scalable scientific-computing and application platforms; fluent in cloud, HPC, data engineering, and software-delivery practices 

• Product Management Discipline — Runs CPP technology as a portfolio of products with clear roadmaps, prioritization, outcome metrics, and stakeholder-managed trade-offs 

• Strategic Partnership — Translates scientific and Development needs into practical, integrated technology and workflow solutions 

• Operational Leadership — Builds reliable, scalable, inspection-ready environments and support models for critical quantitative workflows 

• Regulatory Translation Capability — Understands how quantitative evidence is prepared, reported, reviewed, and used in regulatory settings, and what technology must guarantee to support it 

Leadership & Change Attributes 

• Strong partnership with senior scientific, clinical, and regulatory leaders 

• Comfort operating with regulatory and global Development stakeholders 

• Experience leading technology modernization and change management in scientific user communities—moving teams to new platforms while protecting ongoing program timelines 

• Ability to recruit, develop, and retain highly specialized quantitative talent in a competitive market 

• Experience navigating matrixed organizations and building credibility quickly 

• Commitment to building a collaborative, high-performing culture in a growing team 

What Differentiates Top Candidates 

• Experience as a clinical pharmacology or pharmacometrics technology leader inside a top-tier pharmaceutical R&D or life-sciences technology organization 

• Track record of applications, workflows, or platforms that improved dose selection, quantitative decision-making, or regulatory execution in Development-facing settings 

• Experience deploying workflow automation, AI-enabled capabilities, or advanced analytics in support of end-to-end CPP modeling, reporting, and decision-support operations 

• Demonstrated success building a specialized function from foundational capability to scaled organizational value while operating through strong matrix partnerships 

Why This Role Matters Now 

 

Bristol Myers Squibb is at a pivotal moment, reimagining how technology, data, and AI enable scientific decision-making across Research and Development. Clinical pharmacology and pharmacometrics sit at the center of that shift, shaping how teams translate preclinical insights, make dose and regimen decisions, generate regulatory evidence, and advance programs with greater speed and rigor. This role is BI&T’s technology leader for that domain: it builds the next generation of CPP platforms and ensures that scientists have the modern, validated, integrated tools and automation they need to improve quality, reuse, and accountability across the pipeline. 

#LI-Hybrid

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Brisbane - CA - US: $252,640 - $306,137 Cambridge Crossing: $252,640 - $306,137 Princeton - NJ - US: $229,670 - $278,306 San Diego - CA - US: $252,640 - $306,137

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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R1608355 : Senior Director, Business Insights and Technology- Research (Clinical Pharmacology & Pharmacometrics)