Scientist III - Mass Spec Production (LC-MS/MS)
Kansas City, MO, United StatesYesterday
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Skills
About the role
When you work as a Scientist III in the Mass Spec Bioanalysis Development group at KCAS, you get to further our mission by leveraging your knowledge in bioanalytical and scientific principles to execute and take ownership of significant aspects of studies, from study setup through reporting, as well as contribute to development activities. You will utilize your strong base in scientific principles/theories to assess data integrity and troubleshoot when necessary.
Our Mass Spec Bioanalysis Development team uses LC-MS/MS (Liquid Chromatography–Tandem Mass Spectrometry) techniques and sophisticated sample preparation methods to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including the bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues.
In this role, we will rely on you to:
- Execute and take ownership of key study components including sample preparation, LC-MS/MS analysis, troubleshooting, data analysis, and documentation
- Contribute to method development, qualification, and optimization efforts
- Troubleshoot complex technical issues and recommend solutions
- Analyze and interpret data with minimal oversight
- Prepare data summaries and contribute to report generation
- Ensure compliance of study activities with pertinent portions of study protocol, SOPs & regulatory requirements
- Communicate study progress to senior scientists and management as required
- Provide guidance and mentorship to junior scientific staff
- Perform all aspects of the job in a way that supports company brand and supports company mission, vision, and values
To qualify specifically for this role, you will have:
- Bachelor’s, Master’s, or PhD in Chemistry, Biochemistry or chemical/biochemical engineering, or related field with at least 4–6 years of experience with LC-MS/MS
- Strong experience with bioanalytical sample preparation, quantitative LC-MS/MS, and multi-dimensional chromatography
- Experience contributing to method development, qualification, and complex troubleshooting
- Experience with proteins and peptides as well as small molecule biomarkers is preferred
- Experience with reversed phase and HILIC chromatography at analytical flow rates or protein digestions and immunoaffinity enrichments (hybrid LCMS) is a plus
- Experience working in a regulated environment (GLP/GxP)