Research Associate II - High Throughput Screening Core

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Research Assistant II position is available within the High Throughput Screening (HTS) Core. The HTS Core supports early-stage drug discovery through assay development and optimization, high-throughput small-molecule screening, hit identification and validation, and lead optimization. The Core provides investigators with access to automated screening capabilities, a collection of more than 250,000 small molecules, and scientific expertise in biochemical and cell-based assay development.

We are seeking a highly motivated and collaborative research professional with experience in cell biology, biochemistry, assay development, and/or drug discovery. You will work closely with investigators and support the development, optimization, execution of small molecule screening, hit validation, and quantitative data analysis. The position will involve extensive hands-on laboratory work and close collaboration with HTS Core staff and investigators across multiple drug-discovery and translational research projects.

In addition to traditional HTS approaches, the HTS Core also involves advanced translational screening technologies, including 3D/organoid models imaging and profiling, high-content imaging and image-based phenotypic screening. Experience in one or more of these emerging areas would be highly valued.

As a successful candidate you will:

· Develop, optimize, validate, and miniaturize biochemical and cell-based assays for drug discovery and small-molecule screening.

· Design and execute high-throughput and medium-throughput screening campaigns, including primary screening, hit confirmation, concentration-response studies, counter-screens, and orthogonal/secondary validation assays.

· Utilize and support laboratory automation, liquid handling, multimode detection, and other screening technologies to establish efficient and reproducible drug-discovery workflows.

· Develop and apply high-content imaging and image-based phenotypic assays, including live-cell and multiparametric imaging.

· Manage multiple collaborative projects while maintaining high standards for experimental rigor, reproducibility, data integrity, documentation, and timely project execution.

· Develop and standardize protocols, provide technical guidance and training, and contribute to a collaborative multidisciplinary research environment.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Research Assistant II position is available within the High Throughput Screening (HTS) Core. The HTS Core supports early-stage drug discovery through assay development and optimization, high-throughput small-molecule screening, hit identification and validation, and lead optimization. The Core provides investigators with access to automated screening capabilities, a collection of more than 250,000 small molecules, and scientific expertise in biochemical and cell-based assay development.

We are seeking a highly motivated and collaborative research professional with experience in cell biology, biochemistry, assay development, and/or drug discovery. You will work closely with investigators and support the development, optimization, execution of small molecule screening, hit validation, and quantitative data analysis. The position will involve extensive hands-on laboratory work and close collaboration with HTS Core staff and investigators across multiple drug-discovery and translational research projects.

In addition to traditional HTS approaches, the HTS Core also involves advanced translational screening technologies, including 3D/organoid models imaging and profiling, high-content imaging and image-based phenotypic screening. Experience in one or more of these emerging areas would be highly valued.

As a successful candidate you will:

· Develop, optimize, validate, and miniaturize biochemical and cell-based assays for drug discovery and small-molecule screening.

· Design and execute high-throughput and medium-throughput screening campaigns, including primary screening, hit confirmation, concentration-response studies, counter-screens, and orthogonal/secondary validation assays.

· Utilize and support laboratory automation, liquid handling, multimode detection, and other screening technologies to establish efficient and reproducible drug-discovery workflows.

· Develop and apply high-content imaging and image-based phenotypic assays, including live-cell and multiparametric imaging.

· Manage multiple collaborative projects while maintaining high standards for experimental rigor, reproducibility, data integrity, documentation, and timely project execution.

· Develop and standardize protocols, provide technical guidance and training, and contribute to a collaborative multidisciplinary research environment.

Your qualifications should include:

· Bachelor’s degree. Masters degree preferred

· 2+ years of related experience with a Bachelor’s degree or 1+ year related experience with a Master’s degree.

· Hands-on experience with biochemical and cell-based assay development, optimization, validation, and troubleshooting, including protein biochemical and reporter assays.

· Experience with mammalian cell culture and complex in vitro models, including primary cells, organoids, spheroids, 3D cultures, patient-derived models, and co-culture systems.

· Experience with high-throughput screening (HTS), compound screening, hit validation, lead-optimization workflows, and automated liquid-handling systems.

· Experience with high-content and live-cell imaging, phenotypic screening, and quantitative image analysis.

·