Job Summary: | The Burger laboratory in the Colorado Program for Musculoskeletal Research, within the Department of Orthopedics, is seeking to fill the position of a Research Lead for research relating to vertebrate notochord and intervertebral disc development and disease. In the Burger lab, we are interested in early vertebrate development of the axial and lateral plate mesoderm using zebrafish and mice as models, as well as associated structural birth defects, such as spina bifida, or defects affecting the heart/blood/bone/kidney. We are further interested in how the axial mesoderm develops into the intervertebral discs, and associated underlying molecular mechanisms, as well as intervertebral disc disease, such as IVD degeneration. This position is expected to be the research lead for several ongoing projects, including design of experimental setup, data generation, and data interpretation. All Levels Collaborate with and support Principal Investigators (PI) and other stakeholders with laboratory and research functions Utilize a variety of laboratory techniques required for research projects Independently and creatively identify laboratory solutions Independently Review, develop and implement new or modified laboratory techniques required for research projects Assist Team Leads, Supervisors and/or management with creation and implementation of processes and procedures and quality improvement initiatives Assist and train junior team members.
Senior Level: All Duties listed above plus the following: Assist with developing or develop protocol-specific systems and documents including process flows, training manuals, and Standard Operating Procedures (SOPs). Maintains subject level documentation and prepares documents, equipment and/or supplies Assist with identifying issues related to operational efficiency and shares results with leadership Provide laboratory science expertise and leadership in study design, study oversight, data management, data analysis and manuscript preparation to assist all levels of investigators, researchers and clinicians on new research activities across a wide range of disciplines Serve as a resource to PIs and other stakeholders
Principal Level: All Duties listed above plus the following: Oversee and provide informal leadership to the team members including managing day-to-day priorities, evaluating and redistributing workloads on a temporary basis, and mentoring staff Provide input and feedback to leadership on team members overall performance, performance evaluations, opportunities for development, and process improvement initiatives Identify training and development opportunities for new and existing team members Act as a Subject Matter Expert and authority in the area(s) of zebrafish laboratory work and development of the spine.
Additional Duties & Responsibilities: Wet lab key responsibilities: Conducting molecular biology experiments, such as, but not limited to: PCR, gateway cloning, restriction digest and T4 ligation, Sanger sequencing of plasmid vectors, RNA work, e.g. CRISPR guide RNA generation, mRNA generation, immunohistochemistry/fluorescence, Western blotting, RNA and genomic DNA collection from zebrafish for RNAseq and ATACseq experiments Work and maintain different zebrafish mutant and transgenic strains; including zebrafish husbandry and breeding, embryo collection, genotyping, micro-injection, microscopy of zebrafish embryos, etc. Zebrafish skeletal and non-skeletal tissue harvest for histological analysis, including embedding, sectioning and imaging, and for RNA and genomic DNA isolation
Administrative responsibilities: Ordering consumables and materials, etc. Maintaining laboratory area and equipment in working and clean condition Contributing to animal protocol writing Handling EHS requirements Overseeing training from junior lab members Managing internal and external collaborations with key stake holders Presentation of research findings, e.g. at department internal meetings, national and international scientific meetings Additional responsibilities related to position as assigned by PI
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Why Join Us: | The University of Colorado, Department of Orthopedics is a recognized global leader in the field and Colorado's most trusted orthopedic group for adults and children. Our unique position at the forefront of medical science, education, and practice innovation translates in real-time to the most advanced patient care, unmatched in Colorado and the Rocky Mountain Region. From routine cases to the most complex, we treat every orthopedic condition including injuries and diseases of the bones, joints, nerves, tendons, ligaments, and muscles across many orthopedic specialties. Why work for the University? We have AMAZING benefits and offer exceptional amounts of holiday, vacation and sick leave! The University of Colorado offers an excellent benefits package including: Medical: Multiple plan options Dental: Multiple plan options Additional Insurance: Disability, Life, Vision Retirement 401(a) Plan: Employer contributes 10% of your gross pay Paid Time Off: Accruals over the year Vacation Days: 22/year (maximum accrual 352 hours) Sick Days: 15/year (unlimited maximum accrual) Holiday Days: 15/year Tuition Benefit: Employees have access to this benefit on all CU campuses ECO Pass: Reduced rate RTD Bus and light rail service
There are many additional perks & programs with the CU Advantage. |