Scientist I/II, Biomolecular Discovery

About Magnet Biomedicine

Magnet is a biotechnology company pioneering the discovery of oral molecular glues - small molecules that induce proximity between proteins to modulate their function. Our proprietary TrueGlue(TM) platform is designed to address hard-to-drug targets across cancer and immune-mediated diseases.

With support from ARCH Venture Partners, Newpath Partners, Taiho Ventures, and Eli Lilly, Magnet is advancing internal programs in oncology, immunology, and inflammation. Magnet has also entered into a collaboration and license agreement with Eli Lilly to discover, develop, and commercialize specific molecular glue therapeutics in oncology.

Position Summary

We are seeking a Scientist I/II to join our Biomolecular Discovery team. This role offers an opportunity to directly impact Magnet’s drug discovery efforts through production of high-quality protein reagents suitable for biochemical assays and generation of structural insights. This position will work closely with colleagues across cell biology, chemistry, and proteomics, participating in a highly dynamic collaborative environment where cross-functional teamwork drives progress. If you are a curious scientist dedicated to developing novel small molecule therapeutics for patients in need, we encourage you to consider joining our team at Magnet.

Key Responsibilities 

• Protein Expression: Design plasmid constructs and optimize recombinant protein expression in bacterial (E. coli), insect, or mammalian cell systems
• Protein Purification: Execute multi-step protein purification using affinity, ion-exchange, hydrophobic interaction and size-exclusion chromatography
• Biochemical Characterization: Analyze protein purity, stability and integrity using SDS-PAGE, Western blotting, UV/Vis spectroscopy and fluorescence-based assays
• Biochemical compound profiling: Assess compound perturbation of protein-protein interactions utilizing techniques such as FP, TR-FRET and luminescence
• X-ray Crystallography: Support data collection, analysis and communicate structural insights with collaborators
• Documentation & maintenance: Maintain detailed electronic laboratory notebooks (ELN), calibrate equipment, and prepare comprehensive reports

Required Qualifications and Skills 

• PhD or BS/MS in structural biology, biophysics, biochemistry or related field with 0-5 years (PhD) or 4-10 years (BS/MS) of industrial drug discovery experience 
• Hands-on laboratory experience in recombinant protein construct design, expression and purification
• Highly organized with strong problem-solving and critical thinking skills
• Effective communication skills with the ability to work both independently and collaboratively to progress team objectives

Preferred Qualifications 

• Experience with structural biology methods such as X-ray crystallography, cryo-EM, native MS, or HDxMS is preferred
• Experience in proximity induced small molecule drug discovery is preferred