Analytical Development Senior Research Associate

Job Description

General Summary

Vertex is seeking a Senior Research Associate to join Analytical Development in Boston, MA. This role supports the advancement of transformative medicines by leading analytical chemistry activities across all stages of clinical development. The position is part of the Chromatography Subject Matter Expert (SME) team, focused on small molecules and synthetic peptides/oligonucleotides, with particular emphasis on drug substance, drug product intermediates, and drug product.

Key Duties and Responsibilities:

• Participate in chromatographic method (GC, LC, IC) development, qualification, and validation activities.
• Partner with cross-functional project teams to write and review analytical methods, validation protocols, and reports.
• Serve as a technical expert in chromatographic instrumentation and method development.
• Participate in continuous improvement in phase-appropriate analytical development and validation practices.
• Comply with method development and validation practices across the organization.
• Develop innovative solutions to technical challenges.
• Designs, executes, and interprets experiments, with a high degree of reliability and independence
• Designs development studies with the ability to efficiently assess assay performance
• Conducts experimental troubleshooting on a routine basis
• Contributes collaboratively to team goals, providing technical support where needed
•  Perform other duties as assigned.
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Knowledge and Skills:

• Experience in analytical method development and validation.
• Technical expertise in chromatography and related analytical techniques, including GC, LC, GC-MS, LC-MS, IC.
• Ability in troubleshooting, data review, and interpretation.
• Understanding of pharmaceutical industry regulations, guidelines, and GMP practices.
• Good organization, written, and verbal communication skills.
• Effective in both team-based/matrix environments and independent work.
• Able to manage multiple priorities in a fast-paced environment while maintaining timelines and quality.
• Experience in reference standard qualification (method review and testing with GC and LC)
• Proven technical proficiency and demonstrated skill in designing, executing and interpreting experiments
• Ability to create and support a productive laboratory environment Strong attention to detail.

Education and Experience:

• Bachelor's degree (or equivalent degree) and 2 years of experience in analytical development program or combination of relevant Research and development experience.
• Master's degree (or equivalent degree) and 0-2 years of experience in analytical development program or other analytical support function

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$72,000 - $108,000

Disclosure Statement:

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.  

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com